# hmmsearch :: search profile(s) against a sequence database # HMMER 3.1b2 (February 2015); http://hmmer.org/ # Copyright (C) 2015 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query HMM file: pfam_list/UPF0020.hmm.txt # target sequence database: proteomes/Danio_rerio.fasta # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: UPF0020 [M=197] Accession: PF01170.17 Description: Putative RNA methylase family UPF0020 Scores for complete sequences (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Sequence Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 1.6e-42 145.9 0.0 2.6e-42 145.3 0.0 1.3 1 tr|E9QGU9|E9QGU9_DANRE THUMP domain-containing 3 OS=Dan 3.6e-22 79.5 0.0 1.1e-21 78.0 0.0 1.7 1 tr|X1WET5|X1WET5_DANRE THUMP domain-containing 2 OS=Dan 3.7e-22 79.5 0.0 1.1e-21 78.0 0.0 1.7 1 tr|A0A2R8RIC7|A0A2R8RIC7_DANRE Uncharacterized protein OS=Danio 3.2e-13 50.3 0.0 7.8e-13 49.1 0.0 1.5 1 tr|F1R1R2|F1R1R2_DANRE tRNA methyltransferase 11 homolo 2.7e-06 27.7 0.0 1.2e-05 25.6 0.0 1.9 1 tr|A0A286YB74|A0A286YB74_DANRE LYN proto-oncogene, Src family t 1.5e-05 25.3 0.1 4.1e-05 23.9 0.1 1.8 1 tr|E9QCX1|E9QCX1_DANRE Methyltransferase-like 5 OS=Dani 0.00025 21.3 0.0 0.00054 20.2 0.0 1.6 1 tr|F1QJH5|F1QJH5_DANRE HemK methyltransferase family me 0.0015 18.8 0.0 0.2 11.9 0.0 2.6 2 tr|A0A2R8QIW3|A0A2R8QIW3_DANRE Phosphoethanolamine methyltransf ------ inclusion threshold ------ 0.01 16.0 0.0 0.021 15.0 0.0 1.6 1 sp|Q66L51|COQ5_DANRE 2-methoxy-6-polyprenyl-1,4-benzo 0.022 15.0 0.4 0.16 12.2 0.4 2.3 1 tr|A0A2R8Q256|A0A2R8Q256_DANRE tRNA methyltransferase 2 homolog 0.058 13.6 0.7 0.17 12.0 0.1 2.1 2 tr|F6NSK7|F6NSK7_DANRE Nuclear GTPase, germinal center- 0.26 11.4 0.0 1.9 8.6 0.0 2.0 2 tr|B0S688|B0S688_DANRE rRNA adenine N(6)-methyltransfer Domain annotation for each sequence (and alignments): >> tr|E9QGU9|E9QGU9_DANRE THUMP domain-containing 3 OS=Danio rerio OX=7955 GN=thumpd3 PE=1 SV=2 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 145.3 0.0 1.2e-45 2.6e-42 2 195 .. 261 441 .. 259 443 .. 0.92 Alignments for each domain: == domain 1 score: 145.3 bits; conditional E-value: 1.2e-45 SSS-SS---SS-HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHH CS UPF0020 2 gyRefngpapLketLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrv 88 ++++f gp++L++tLA++++rl++ + ++++DPmCG+G+i++E+a+ ++n + +++ ++ + +++++ + tr|E9QGU9|E9QGU9_DANRE 261 NITHF-GPTTLRSTLAYGMLRLCKPQVSDVIVDPMCGTGAIPLEGAMEWQNSFF-------------IAGDNNGTAVSRSVNNIKHI 333 55555.5**********************************************4.............4457889999********** PP HHHHHHHHHHTT-GGGEEEEE--GGG--STTS---EEEE----------HHHHHHHHHHHHHHHHHH-TT...-EEEEEESSHHHHH CS UPF0020 89 vqgareNaekagvgdliefsqadaakLrlkegevdvivtnpPYGerlgskkalekLYseflrelkrvlrgg.grlvlltsenkalek 174 ++++++ + g+ +++q+d ++L+ ++++vd+i+t++P+G+r+gs k++++LY+ +lre++rv++ g g+++llt+++k+++k tr|E9QGU9|E9QGU9_DANRE 334 LKKTQDGGSPSGL--PLDIVQWDLCNLPMRSSSVDIIITDMPFGKRVGSRKKNWELYPLCLREMARVCKPGtGKAALLTQDKKCFTK 418 ****998888776..56789********9999*************************************999*************** PP CC---..ESEEEEEEETTEEEEE CS UPF0020 175 aleer..alrkvkeknvklglll 195 al ++ ++k + ++v++g+l+ tr|E9QGU9|E9QGU9_DANRE 419 ALLQMggLWKKLHTVWVNVGGLH 441 **999999************998 PP >> tr|X1WET5|X1WET5_DANRE THUMP domain-containing 2 OS=Danio rerio OX=7955 GN=thumpd2 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 78.0 0.0 4.9e-25 1.1e-21 4 177 .. 225 377 .. 223 395 .. 0.89 Alignments for each domain: == domain 1 score: 78.0 bits; conditional E-value: 4.9e-25 S-SS---SS-HHHHHHHHHHT.T--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHH CS UPF0020 4 RefngpapLketLAaalvrla.gwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvv 89 R + + L++t+A a+ l+ + ++ ++lDPmCG G++l+Eaa+ +n++ + g+D d + + tr|X1WET5|X1WET5_DANRE 225 RSYMKHNGLRSTIAWAMTSLCpDELNNCVILDPMCGVGAVLLEAAQEYSNAV------------------------FLGMDTDGSQL 287 77888899************955667889***********************........................99********* PP HHHHHHHHHTT-GGGEEEEE--GGG--STTS---EEEE----------HHHHHHHHHHHHHHHHHH-TT..-EEEEEESS..HHHHH CS UPF0020 90 qgareNaekagvgdliefsqadaakLrlkegevdvivtnpPYGerlgskkalekLYseflrelkrvlrgggrlvlltsen..kalek 174 q+a eN ++ g+++++++ q a +++l++g vd+++++ P+G++ + ++ + + +lre++rvlr gg lvll+s + +l+k tr|X1WET5|X1WET5_DANRE 288 QKAAENVKASGMEGRVQLLQSSALEIPLADGMVDAVLCDVPFGRKFSCSSDMTTALPLLLREMERVLRVGGHLVLLLSLQlsAQLKK 374 ****************************************************9999*****************99986431145555 PP CC- CS UPF0020 175 ale 177 +++ tr|X1WET5|X1WET5_DANRE 375 IIC 377 555 PP >> tr|A0A2R8RIC7|A0A2R8RIC7_DANRE Uncharacterized protein OS=Danio rerio OX=7955 GN=thumpd2 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 78.0 0.0 4.9e-25 1.1e-21 4 177 .. 225 377 .. 223 395 .. 0.89 Alignments for each domain: == domain 1 score: 78.0 bits; conditional E-value: 4.9e-25 S-SS---SS-HHHHHHHHHHT.T--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEE CS UPF0020 4 RefngpapLketLAaalvrla.gwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklyg 81 R + + L++t+A a+ l+ + ++ ++lDPmCG G++l+Eaa+ +n++ + g tr|A0A2R8RIC7|A0A2R8RIC7_DANRE 225 RSYMKHNGLRSTIAWAMTSLCpDELNNCVILDPMCGVGAVLLEAAQEYSNAV------------------------FLG 279 77888899************955667889***********************........................99* PP EES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--STTS---EEEE----------HHHHHHHHHHHHHHHHHH-TT.. CS UPF0020 82 sDldrrvvqgareNaekagvgdliefsqadaakLrlkegevdvivtnpPYGerlgskkalekLYseflrelkrvlrggg 160 +D d + +q+a eN ++ g+++++++ q a +++l++g vd+++++ P+G++ + ++ + + +lre++rvlr gg tr|A0A2R8RIC7|A0A2R8RIC7_DANRE 280 MDTDGSQLQKAAENVKASGMEGRVQLLQSSALEIPLADGMVDAVLCDVPFGRKFSCSSDMTTALPLLLREMERVLRVGG 358 ************************************************************9999*************** PP -EEEEEESS..HHHHHCC- CS UPF0020 161 rlvlltsen..kalekale 177 lvll+s + +l+k+++ tr|A0A2R8RIC7|A0A2R8RIC7_DANRE 359 HLVLLLSLQlsAQLKKIIC 377 **99986431145555555 PP >> tr|F1R1R2|F1R1R2_DANRE tRNA methyltransferase 11 homolog OS=Danio rerio OX=7955 GN=trmt11 PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 49.1 0.0 3.7e-16 7.8e-13 3 140 .. 192 322 .. 191 326 .. 0.91 Alignments for each domain: == domain 1 score: 49.1 bits; conditional E-value: 3.7e-16 SS-SS---SS-HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHH CS UPF0020 3 yRefngpapLketLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvv 89 +R+f g++++ + L+ + + a++k+++ +DP+ G+G++l+ ga++ + ++ + + ++ r+++k +g D + tr|F1R1R2|F1R1R2_DANRE 192 KRHFIGNTSMDAGLSFIMANHAKVKANDLVYDPFVGTGSLLVACSHFGAYVC---GTDIDYNTIHGIGKASRKNQKWRGPDENI--- 272 79****************************************9999999999...56778889999999999*********876... PP HHHHHHHHHTT-GGG.EEEEE--GGG--.STTS---EEEE----------HHH CS UPF0020 90 qgareNaekagvgdl.iefsqadaakLr.lkegevdvivtnpPYGerlgskka 140 r N++++g ++l +++ + da kL ++++++d+i+t+pPYG+r ++ ++ tr|F1R1R2|F1R1R2_DANRE 273 ---RANLRQYGAENLyVDVMVSDASKLVwRRNAQFDAIITDPPYGIRESTRRT 322 ...57*******98648999*******999999**************887765 PP >> tr|A0A286YB74|A0A286YB74_DANRE LYN proto-oncogene, Src family tyrosine kinase OS=Danio rerio OX=7955 GN=lyn PE=1 SV= # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 25.6 0.0 5.5e-09 1.2e-05 24 132 .. 639 720 .. 627 723 .. 0.90 Alignments for each domain: == domain 1 score: 25.6 bits; conditional E-value: 5.5e-09 TT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHHHHHHHHHTT-G CS UPF0020 24 agwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqgareNaekagvg 102 + ++e ++D +CG G+ +I al g++++ g+D+d+ ++ a+ Na +gv+ tr|A0A286YB74|A0A286YB74_DANRE 639 QDCFNTELIIDAFCGVGGNAIQFALTGKRVI--------------------------GIDIDPVRLALAQHNAAVYGVE 691 5566788999999999999999999999999..........................********************** PP GGEEEEE--GGG--STTS---EEEE----- CS UPF0020 103 dliefsqadaakLrlkegevdvivtnpPYG 132 ++i+f q d+ +L ++ d++ pP+G tr|A0A286YB74|A0A286YB74_DANRE 692 QRIDFLQGDFLQLA-PHLRGDMVFLSPPWG 720 **************.77788*********9 PP >> tr|E9QCX1|E9QCX1_DANRE Methyltransferase-like 5 OS=Danio rerio OX=7955 GN=mettl5 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 23.9 0.1 1.9e-08 4.1e-05 79 151 .. 74 146 .. 27 175 .. 0.85 Alignments for each domain: == domain 1 score: 23.9 bits; conditional E-value: 1.9e-08 EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--.STTS---EEEE----------HHHHHHHHHHHHHH CS UPF0020 79 lygsDldrrvvqgareNaekagvgdliefsqadaakLr.lkegevdvivtnpPYGerlgskkalekLYseflre 151 +g+D+d+ +++ r N e+ ++ + i+++q d++++ +++d+++ npP+G + ++ +++ L +++ + tr|E9QCX1|E9QCX1_DANRE 74 CVGFDIDEDALDIFRGNVEEFELPN-IDVVQCDVCSIGsSYAKKFDTVIMNPPFGTKHNQGIDMQFLQTAISMA 146 68********************986.788888*****9755669***********9998887777776666554 PP >> tr|F1QJH5|F1QJH5_DANRE HemK methyltransferase family member 1 OS=Danio rerio OX=7955 GN=hemk1 PE=4 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 20.2 0.0 2.5e-07 0.00054 76 133 .. 186 247 .. 171 259 .. 0.84 Alignments for each domain: == domain 1 score: 20.2 bits; conditional E-value: 2.5e-07 H--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--....STTS---EEEE------ CS UPF0020 76 elklygsDldrrvvqgareNaekagvgdliefsqadaakLr....lkegevdvivtnpPYGe 133 +l+++++D + +v + eNa++ g++d+ e+ +d+ k k + vd iv+npPY tr|F1QJH5|F1QJH5_DANRE 186 QLRVFALDQSQDAVCLTMENANRLGLQDRLEVHHLDVVKDAdvilSKCNPVDFIVSNPPYIL 247 56799***************************99998653334445777***********65 PP >> tr|A0A2R8QIW3|A0A2R8QIW3_DANRE Phosphoethanolamine methyltransferase OS=Danio rerio OX=7955 GN=pmt PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 11.9 0.0 9.2e-05 0.2 78 150 .. 75 142 .. 59 147 .. 0.77 2 ? 3.8 0.0 0.027 57 78 125 .. 313 359 .. 306 363 .. 0.83 Alignments for each domain: == domain 1 score: 11.9 bits; conditional E-value: 9.2e-05 -EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--STTS---EEEE----------HHHHHHHHHHHHH CS UPF0020 78 klygsDldrrvvqgareNaekagvgdliefsqadaakLrlkegevdvivtnpPYGerlgskkalekLYseflr 150 ++ ++D+ ++ v++ N + g +++ef qad++kL +e+++d++ +n + s ++l+ L ++flr tr|A0A2R8QIW3|A0A2R8QIW3_DANRE 75 HVTAVDFMEKFVEK---NRQDNGHLGSVEFIQADVTKLDFPEHSFDLVFSN--WLLMYLSDQELQLLAEKFLR 142 47788898988875...7777888899************9**********9..55555555555555555555 PP == domain 2 score: 3.8 bits; conditional E-value: 0.027 -EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--STTS---EE CS UPF0020 78 klygsDldrrvvqgareNaekagvgdliefsqadaakLrlkegevdvi 125 ++ g+Dl +++v+ a e a k ++ l++f++ da+k r +++ +dv+ tr|A0A2R8QIW3|A0A2R8QIW3_DANRE 313 EVLGMDLSSNMVEIAMERAVKEKLP-LVQFEVSDATKRRFPDAAFDVV 359 589****************998876.7899999999877777778877 PP >> sp|Q66L51|COQ5_DANRE 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Danio rerio OX=7955 GN=coq5 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 15.0 0.0 1e-05 0.021 20 124 .. 98 212 .. 96 245 .. 0.73 Alignments for each domain: == domain 1 score: 15.0 bits; conditional E-value: 1e-05 HHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SS.........HHHHHHHHHH..HH--EEEEES-HHHHHHHHHHHH CS UPF0020 20 lvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvle.........lkaeaeeear..aelklygsDldrrvvqgareNae 97 l+ + + +pg +llD G+G i ++++ + r ++ + + +++ ++ + + D+++++++ +++ ae sp|Q66L51|COQ5_DANRE 98 LLHIMNPQPGLRLLDTAGGTGDISFRFLEYTRSMYDRQQRLRAKSqqtpswkdiA-GHYVSDEEgpPQSRAVVCDINKEMLKVGKQRAE 185 5666677777777777777777765544444444443344333334566655532.333333334455558889*************** PP HTT-GGGEEEEE--GGG--STTS---E CS UPF0020 98 kagvgdliefsqadaakLrlkegevdv 124 ag++ ++++ da +L+ +++++d+ sp|Q66L51|COQ5_DANRE 186 DAGITTGLSWVAGDAEELPFDDDQFDM 212 *******************77777775 PP >> tr|A0A2R8Q256|A0A2R8Q256_DANRE tRNA methyltransferase 2 homolog A OS=Danio rerio OX=7955 GN=trmt2a PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.2 0.4 7.3e-05 0.16 8 79 .. 436 500 .. 432 528 .. 0.72 Alignments for each domain: == domain 1 score: 12.2 bits; conditional E-value: 7.3e-05 ---SS-HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--E CS UPF0020 8 gpapLketLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelkl 79 ++p e L +a + a+++++++ lD CG+Gti I a +++++ + l +ea ++a+a++k tr|A0A2R8Q256|A0A2R8Q256_DANRE 436 TNTPAAEILYSAVGEWAQLDQDSTVLDVCCGTGTIGISLAKRVKKVIGIE-------LCQEAVKDAEANAKA 500 566666777788889999*******************9999999999333.......333333333333332 PP >> tr|F6NSK7|F6NSK7_DANRE Nuclear GTPase, germinal center-associated, tandem duplicate 1 OS=Danio rerio OX=7955 GN=nugg # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 12.0 0.1 8.1e-05 0.17 65 111 .. 802 848 .. 767 858 .. 0.79 2 ? -2.8 0.0 2.9 6.1e+03 142 165 .. 1331 1354 .. 1328 1363 .. 0.73 Alignments for each domain: == domain 1 score: 12.0 bits; conditional E-value: 8.1e-05 HHHHHHHHHHHH--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE-- CS UPF0020 65 lkaeaeeearaelklygsDldrrvvqgareNaekagvgdliefsqad 111 ++ +++++ + +yg+D d++ ++ ++Na++a+++++ + +++ tr|F6NSK7|F6NSK7_DANRE 802 TDERTDTDNERIIAVYGADADKKSLEELKKNAKYAEIDHFLSTEKKT 848 44566677778888*************************99988765 PP == domain 2 score: -2.8 bits; conditional E-value: 2.9 HHHHHHHHHHHHHH-TT..-EEEE CS UPF0020 142 ekLYseflrelkrvlrgggrlvll 165 e+L s+++r+++r +++++++ l+ tr|F6NSK7|F6NSK7_DANRE 1331 ESLKSKLSRSMERSFSQSSKASLM 1354 678889999999999996665554 PP >> tr|B0S688|B0S688_DANRE rRNA adenine N(6)-methyltransferase OS=Danio rerio OX=7955 GN=dimt1l PE=1 SV=1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 8.6 0.0 0.00088 1.9 75 133 .. 70 126 .. 42 150 .. 0.89 2 ? 0.3 0.0 0.33 7e+02 164 194 .. 223 253 .. 216 256 .. 0.81 Alignments for each domain: == domain 1 score: 8.6 bits; conditional E-value: 0.00088 HH--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--STTS---EEEE------ CS UPF0020 75 aelklygsDldrrvvqgareNaekagvgdliefsqadaakLrlkegevdvivtnpPYGe 133 + k+++ +ld r+v+ ++ + + ++++ ++ d+ k +l+ +dv v+n+PY + tr|B0S688|B0S688_DANRE 70 KAKKVVACELDTRLVAELQKRVQCTPMQNKLQILIGDVLKTELPF--FDVCVANLPYQI 126 445699********************************9999777..9*********76 PP == domain 2 score: 0.3 bits; conditional E-value: 0.33 EEEESSHHHHHCC---ESEEEEEEETTEEEE CS UPF0020 164 lltsenkalekaleeralrkvkeknvklgll 194 + + +nk+l +a++++a++k ekn k+ + tr|B0S688|B0S688_DANRE 223 AFVRKNKMLSAAFKSAAVEKLLEKNYKIHCS 253 4456788899999999*******99999986 PP Internal pipeline statistics summary: ------------------------------------- Query model(s): 1 (197 nodes) Target sequences: 25687 (13798380 residues searched) Passed MSV filter: 734 (0.0285748); expected 513.7 (0.02) Passed bias filter: 580 (0.0225795); expected 513.7 (0.02) Passed Vit filter: 65 (0.00253046); expected 25.7 (0.001) Passed Fwd filter: 12 (0.000467162); expected 0.3 (1e-05) Initial search space (Z): 25687 [actual number of targets] Domain search space (domZ): 12 [number of targets reported over threshold] # CPU time: 0.26u 0.01s 00:00:00.27 Elapsed: 00:00:00.10 # Mc/sec: 27182.81 // [ok]