# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/UPF0020.hmm.txt
# target sequence database: proteomes/Drosophila_melanogaster.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: UPF0020 [M=197]
Accession: PF01170.17
Description: Putative RNA methylase family UPF0020
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
1.6e-12 47.1 0.0 3.8e-11 42.7 0.0 2.8 2 tr|Q960G1|Q960G1_DROME SD03208p OS=Drosophila melanogaster O
5.4e-06 25.9 0.1 7.1e-05 22.2 0.1 2.3 1 tr|Q9VEA4|Q9VEA4_DROME Trimethylguanosine synthase 1 OS=Dros
0.0031 16.8 0.2 0.083 12.2 0.2 2.2 1 tr|Q8IQN1|Q8IQN1_DROME Uncharacterized protein, isoform B OS
0.008 15.5 0.0 0.013 14.9 0.0 1.5 1 tr|Q8MSW4|Q8MSW4_DROME LD25448p2 OS=Drosophila melanogaster
0.01 15.2 0.0 0.021 14.1 0.0 1.5 1 sp|Q9VJ34|GSTCD_DROME Glutathione S-transferase C-terminal
------ inclusion threshold ------
0.029 13.7 0.0 0.051 12.9 0.0 1.4 1 tr|Q9VMD3|Q9VMD3_DROME Uncharacterized protein, isoform A OS
0.11 11.8 0.0 0.19 11.0 0.0 1.4 1 tr|Q9VQF8|Q9VQF8_DROME GH13185p2 OS=Drosophila melanogaster
Domain annotation for each sequence (and alignments):
>> tr|Q960G1|Q960G1_DROME SD03208p OS=Drosophila melanogaster OX=7227 GN=Dmel\CG1074 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 42.7 0.0 2e-14 3.8e-11 3 139 .. 189 318 .. 188 326 .. 0.77
2 ? -0.8 0.0 0.41 8.2e+02 137 166 .. 341 370 .. 338 375 .. 0.87
Alignments for each domain:
== domain 1 score: 42.7 bits; conditional E-value: 2e-14
SS-SS---SS-HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHH.HH--EEEEES-HHH CS
UPF0020 3 yRefngpapLketLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeear.aelklygsDldrrv 88
R+f g++++ ++L+ + + a +++g+ +DP+ G+G++l+ aa g ++ + ++++++ r ++ ++d+
tr|Q960G1|Q960G1_DROME 189 HRKFIGNTSMDAQLSLLMANQAMVRNGDLVFDPFVGTGSLLVSAAKWGGYVLGADIDYMMVHARC------RpSRITQKVREKDE-- 267
699************************************************94333222222222......22222222334444.. PP
HHHHHHHHHHTT-GGG.EEEEE--GGG--.STTS---EEEE----------HH CS
UPF0020 89 vqgareNaekagvgdl.iefsqadaakLr.lkegevdvivtnpPYGerlgskk 139
r N++++g +d+ +++++ad+ + +++ ++d i+t+pPYG+r ++k
tr|Q960G1|Q960G1_DROME 268 --SIRANLKQYGCADRyMDVVVADFSNPVwHSRISFDCIITDPPYGIREATEK 318
..4589*****99886368999999875556888*************977765 PP
== domain 2 score: -0.8 bits; conditional E-value: 0.41
-HHHHHHHHHHHHHHHHHH-TT..-EEEEE CS
UPF0020 137 skkalekLYseflrelkrvlrgggrlvllt 166
s+ +l++LY +l+ +r+l+ ggrlv +
tr|Q960G1|Q960G1_DROME 341 SHYSLQSLYGDLLEFSARHLKLGGRLVCWI 370
677899*******************99765 PP
>> tr|Q9VEA4|Q9VEA4_DROME Trimethylguanosine synthase 1 OS=Drosophila melanogaster OX=7227 GN=Tgs1 PE=4 SV=3
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 22.2 0.1 3.6e-08 7.1e-05 76 138 .. 320 383 .. 291 445 .. 0.80
Alignments for each domain:
== domain 1 score: 22.2 bits; conditional E-value: 3.6e-08
H--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--.STTS---EEEE----------H CS
UPF0020 76 elklygsDldrrvvqgareNaekagvgdliefsqadaakLr.lkegevdvivtnpPYGerlgsk 138
+++++D+d++ ++ a+ Na +gv+++ief ad+ ++ ++ +v+ pP+G +k
tr|Q9VEA4|Q9VEA4_DROME 320 CGRVIAVDIDAEKLAMAKHNAGIYGVAHKIEFIHADFLQFAaSTKLRPNVVFLSPPWGGPDYQK 383
33478************************************544447889999****9655555 PP
>> tr|Q8IQN1|Q8IQN1_DROME Uncharacterized protein, isoform B OS=Drosophila melanogaster OX=7227 GN=Dmel\CG32152 PE=3 SV
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 12.2 0.2 4.2e-05 0.083 36 128 .. 50 115 .. 40 119 .. 0.77
Alignments for each domain:
== domain 1 score: 12.2 bits; conditional E-value: 4.2e-05
T-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--STTS-- CS
UPF0020 36 mCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqgareNaekagvgdliefsqadaakLrlkegev 122
CG+Gt+++ aa++ga+++ y++D ++v+ + ++ g ++ i++ + +++L+l++ +v
tr|Q8IQN1|Q8IQN1_DROME 50 CCGTGTLALMAAQMGAKRV-------------------------YAVDY-SKVTGYTTLVVRQNGYEGVITVMNGRMKDLKLPT-KV 109
5****************99.........................67775.4566667777777777777777777777777555.67 PP
-EEEE- CS
UPF0020 123 dvivtn 128
d i++n
tr|Q8IQN1|Q8IQN1_DROME 110 DGIICN 115
777777 PP
>> tr|Q8MSW4|Q8MSW4_DROME LD25448p2 OS=Drosophila melanogaster OX=7227 GN=CG42374-RA PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 14.9 0.0 6.4e-06 0.013 79 137 .. 77 136 .. 32 171 .. 0.85
Alignments for each domain:
== domain 1 score: 14.9 bits; conditional E-value: 6.4e-06
EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--..STTS---EEEE---------- CS
UPF0020 79 lygsDldrrvvqgareNaekagvgdliefsqadaakLr..lkegevdvivtnpPYGerlgs 137
+g++ld +v++ r N ++++ + ++ + ad+ +L + e+++d+++ npP+G + ++
tr|Q8MSW4|Q8MSW4_DROME 77 TVGFELDGDAVDTFRGNVVEMELPN-VDCVRADVLQLIgsKWEKSFDTVLMNPPFGTKHNA 136
6899*****************9985.889999*****9887888************97655 PP
>> sp|Q9VJ34|GSTCD_DROME Glutathione S-transferase C-terminal domain-containing protein homolog OS=Drosophila melanogas
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 14.1 0.0 1.1e-05 0.021 14 75 .. 374 436 .. 366 450 .. 0.79
Alignments for each domain:
== domain 1 score: 14.1 bits; conditional E-value: 1.1e-05
HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHH...H CS
UPF0020 14 etLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeear...a 75
e+LA a v la +pg++++D +G+G ++I al n+ + + ++++ l++ +++++ +
sp|Q9VJ34|GSTCD_DROME 374 ENLANAVVSLA--QPGDRIVDFCSGTGHLAILLALKLPNCTIIVMENKAFSLLQAQKRSNElglT 436
78999*99997..79******999*****************877766666666665555555443 PP
>> tr|Q9VMD3|Q9VMD3_DROME Uncharacterized protein, isoform A OS=Drosophila melanogaster OX=7227 GN=HemK1 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 12.9 0.0 2.6e-05 0.051 80 133 .. 173 231 .. 154 236 .. 0.78
Alignments for each domain:
== domain 1 score: 12.9 bits; conditional E-value: 2.6e-05
EEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG...--..STTS---EEEE------ CS
UPF0020 80 ygsDldrrvvqgareNaekagvgdliefsqadaak...Lr..lkegevdvivtnpPYGe 133
+++ ++++ a eNa+ g+ ++ e+ + + + L+ lk++++d+i++npPY +
tr|Q9VMD3|Q9VMD3_DROME 173 TAIERSKAATVLAAENAKMLGLLNRFEVHNHTMEEdkyLPeaLKDKKYDLIISNPPYVK 231
5667777788889999999999998888776665422266877788***********65 PP
>> tr|Q9VQF8|Q9VQF8_DROME GH13185p2 OS=Drosophila melanogaster OX=7227 GN=HemK2 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 11.0 0.0 9.4e-05 0.19 79 147 .. 70 135 .. 53 149 .. 0.76
Alignments for each domain:
== domain 1 score: 11.0 bits; conditional E-value: 9.4e-05
EEEEES-HHHHHHHHHHHHHTT-G.GGEEEEE--GGG--STTS---EEEE----------HHHHHHHHHH CS
UPF0020 79 lygsDldrrvvqgareNaekagvg.dliefsqadaakLrlkegevdvivtnpPYGerlgskkalekLYse 147
+ D+++++ +++r+ a + g d+i s a +Lr ++ +vdv++ npPY +++ + +++ s+
tr|Q9VQF8|Q9VQF8_DROME 70 CLATDINPKACNATRRTATRNGARlDSIRCSL--ADALR-PR-SVDVLLFNPPYVVTSDEELQTQQFDSH 135
568999*****999999998887525565555..55567.77.9**********9888888777776555 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (197 nodes)
Target sequences: 13786 (7394964 residues searched)
Passed MSV filter: 466 (0.0338024); expected 275.7 (0.02)
Passed bias filter: 332 (0.0240824); expected 275.7 (0.02)
Passed Vit filter: 33 (0.00239373); expected 13.8 (0.001)
Passed Fwd filter: 7 (0.000507761); expected 0.1 (1e-05)
Initial search space (Z): 13786 [actual number of targets]
Domain search space (domZ): 7 [number of targets reported over threshold]
# CPU time: 0.14u 0.01s 00:00:00.15 Elapsed: 00:00:00.05
# Mc/sec: 29136.16
//
[ok]