# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/UPF0020.hmm.txt
# target sequence database: proteomes/Homo_sapiens.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: UPF0020 [M=197]
Accession: PF01170.17
Description: Putative RNA methylase family UPF0020
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
3.3e-49 169.5 0.0 5.3e-49 168.9 0.0 1.3 1 sp|Q9BV44|THUM3_HUMAN THUMP domain-containing protein 3 OS
1.4e-27 98.9 0.0 4.8e-25 90.7 0.0 2.1 2 tr|H7C3J3|H7C3J3_HUMAN THUMP domain-containing protein 3 (F
9.6e-26 92.9 0.0 2.9e-25 91.4 0.0 1.8 1 sp|Q9BTF0|THUM2_HUMAN THUMP domain-containing protein 2 OS
2.3e-17 65.6 0.0 3.7e-17 64.9 0.0 1.3 1 tr|H7C0R6|H7C0R6_HUMAN THUMP domain-containing protein 3 (F
2.3e-11 46.0 0.0 4.5e-11 45.1 0.0 1.4 1 tr|F2Z2Q4|F2Z2Q4_HUMAN tRNA (guanine(10)-N2)-methyltransfer
4.1e-11 45.2 0.0 9e-11 44.1 0.0 1.5 1 sp|Q7Z4G4|TRM11_HUMAN tRNA (guanine(10)-N2)-methyltransfer
4.1e-11 45.2 0.0 8.8e-11 44.1 0.0 1.4 1 sp|Q7Z4G4-2|TRM11_HUMAN Isoform 2 of tRNA (guanine(10)-N2)-m
2.6e-09 39.3 0.0 4.9e-09 38.4 0.0 1.4 1 tr|H0Y768|H0Y768_HUMAN tRNA (guanine(10)-N2)-methyltransfer
2e-07 33.1 0.1 1.4e-06 30.4 0.1 2.0 1 tr|B8ZZE3|B8ZZE3_HUMAN Methyltransferase like 5, isoform CR
2.5e-07 32.9 0.2 1.7e-06 30.2 0.2 2.0 1 sp|Q9NRN9|METL5_HUMAN Methyltransferase-like protein 5 OS=
3e-07 32.6 0.1 2.5e-06 29.6 0.1 2.0 1 tr|E7EMN2|E7EMN2_HUMAN Methyltransferase-like protein 5 OS=
4.1e-07 32.2 0.2 2.6e-06 29.5 0.2 2.0 1 tr|B8ZZC8|B8ZZC8_HUMAN Methyltransferase-like protein 5 OS=
3.8e-05 25.7 0.0 0.00014 23.9 0.0 1.8 1 sp|Q96RS0|TGS1_HUMAN Trimethylguanosine synthase OS=Homo
4.5e-05 25.5 0.0 7.4e-05 24.8 0.0 1.2 1 sp|Q7Z4G4-3|TRM11_HUMAN Isoform 3 of tRNA (guanine(10)-N2)-m
0.00056 21.9 0.0 0.0012 20.8 0.0 1.5 1 sp|Q9Y5R4|HEMK1_HUMAN HemK methyltransferase family member
0.0014 20.6 0.0 0.0017 20.3 0.0 1.3 1 tr|H7C0M7|H7C0M7_HUMAN Methyltransferase-like protein 5 (Fr
------ inclusion threshold ------
0.018 17.0 0.0 0.032 16.2 0.0 1.3 1 tr|F2Z2W7|F2Z2W7_HUMAN tRNA (uracil-5-)-methyltransferase h
0.46 12.4 0.5 10 8.0 0.5 2.2 1 sp|Q8IZ69-2|TRM2A_HUMAN Isoform 2 of tRNA (uracil-5-)-methyl
0.6 12.0 0.5 12 7.8 0.5 2.2 1 sp|Q8IZ69|TRM2A_HUMAN tRNA (uracil-5-)-methyltransferase h
0.8 11.6 0.0 1.8 10.5 0.0 1.6 1 tr|F8VVX6|F8VVX6_HUMAN 2-methoxy-6-polyprenyl-1,4-benzoquin
1.1 11.2 0.0 1.8 10.4 0.0 1.3 1 tr|K7ENP1|K7ENP1_HUMAN tRNA (guanine(10)-N2)-methyltransfer
Domain annotation for each sequence (and alignments):
>> sp|Q9BV44|THUM3_HUMAN THUMP domain-containing protein 3 OS=Homo sapiens GN=THUMPD3 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 168.9 0.0 1.3e-52 5.3e-49 2 195 .. 294 476 .. 292 478 .. 0.95
Alignments for each domain:
== domain 1 score: 168.9 bits; conditional E-value: 1.3e-52
SSS-SS---SS-HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHH CS
UPF0020 2 gyRefngpapLketLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvv 89
++++f gp++L++tLA++++rl++ p + ++DPmCG+G+i+IE+a+ ++++ +++ ++++ + +++++++++++
sp|Q9BV44|THUM3_HUMAN 294 NITHF-GPTTLRSTLAYGMLRLCDPLPYDIIVDPMCGTGAIPIEGATEWSDCFHIAG-------------DNNPLAVNRAANNIASLL 367
55555.5**********************************************7665.............8999999*********** PP
HHHHHHHHHTT-GGGEEEEE--GGG--STTS---EEEE----------HHHHHHHHHHHHHHHHHH-TT...-EEEEEESSHHHHHCC CS
UPF0020 90 qgareNaekagvgdliefsqadaakLrlkegevdvivtnpPYGerlgskkalekLYseflrelkrvlrgg.grlvlltsenkalekal 176
++++ + k +g i+++q+d+++L+l++g+vd+ivt++P+G+r+gskk++++LY+++lre++rv+ gr+vllt+++k+++kal
sp|Q9BV44|THUM3_HUMAN 368 TKSQIKEGKPSWGLPIDAVQWDICNLPLRTGSVDIIVTDLPFGKRMGSKKRNWNLYPACLREMSRVCTPTtGRAVLLTQDTKCFTKAL 455
*******************************************************************9988***************** PP
---..ESEEEEEEETTEEEEE CS
UPF0020 177 eer..alrkvkeknvklglll 195
+ + +rkv ++v++g+l+
sp|Q9BV44|THUM3_HUMAN 456 SGMrhVWRKVDTVWVNVGGLR 476
*99899************987 PP
>> tr|H7C3J3|H7C3J3_HUMAN THUMP domain-containing protein 3 (Fragment) OS=Homo sapiens GN=THUMPD3 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 7.0 0.0 0.0049 21 2 23 .. 127 147 .. 125 151 .. 0.78
2 ! 90.7 0.0 1.1e-28 4.8e-25 100 195 .. 149 247 .. 146 249 .. 0.95
Alignments for each domain:
== domain 1 score: 7.0 bits; conditional E-value: 0.0049
SSS-SS---SS-HHHHHHHHHH CS
UPF0020 2 gyRefngpapLketLAaalvrl 23
++++f gp++L++tLA++++
tr|H7C3J3|H7C3J3_HUMAN 127 NITHF-GPTTLRSTLAYGMLSK 147
55555.5************975 PP
== domain 2 score: 90.7 bits; conditional E-value: 1.1e-28
T-GGGEEEEE--GGG--STTS---EEEE----------HHHHHHHHHHHHHHHHHH-TT...-EEEEEESSHHHHHCC---..ESEE CS
UPF0020 100 gvgdliefsqadaakLrlkegevdvivtnpPYGerlgskkalekLYseflrelkrvlrgg.grlvlltsenkalekaleer..alrk 183
+g i+++q+d+++L+l++g+vd+ivt++P+G+r+gskk++++LY+++lre++rv+ gr+vllt+++k+++kal+ + +rk
tr|H7C3J3|H7C3J3_HUMAN 149 SWGLPIDAVQWDICNLPLRTGSVDIIVTDLPFGKRMGSKKRNWNLYPACLREMSRVCTPTtGRAVLLTQDTKCFTKALSGMrhVWRK 235
57889****************************************************9988******************99899*** PP
EEEEETTEEEEE CS
UPF0020 184 vkeknvklglll 195
v ++v++g+l+
tr|H7C3J3|H7C3J3_HUMAN 236 VDTVWVNVGGLR 247
*********987 PP
>> sp|Q9BTF0|THUM2_HUMAN THUMP domain-containing protein 2 OS=Homo sapiens GN=THUMPD2 PE=2 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 91.4 0.0 6.9e-29 2.9e-25 4 170 .. 274 412 .. 272 433 .. 0.92
Alignments for each domain:
== domain 1 score: 91.4 bits; conditional E-value: 6.9e-29
S-SS---SS-HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHH CS
UPF0020 4 RefngpapLketLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqg 91
R + + a L++t+A a+ la++k+g lDPmCG Gtil+Eaa + +++ +g+D + + g
sp|Q9BTF0|THUM2_HUMAN 274 RAYIKTAGLRSTIAWAMASLADIKAGAFVLDPMCGLGTILLEAAKEWPDVY------------------------YVGADVSDSQLLG 337
788899*********************************************........................79*********** PP
HHHHHHHTT-GGGEEEEE--GGG--STTS---EEEE----------HHHHHHHHHHHHHHHHHH-TT..-EEEEEESSH CS
UPF0020 92 areNaekagvgdliefsqadaakLrlkegevdvivtnpPYGerlgskkalekLYseflrelkrvlrgggrlvlltsenk 170
+ +N+++ag++d+ie+ + + +L+l++++vd+i+++ P+G++ + k+++ ++l+e++rvl+ gg +vll+se+
sp|Q9BTF0|THUM2_HUMAN 338 TWDNLKAAGLEDKIELLKISVIELPLPSESVDIIISDIPFGKKFKLGKDIK----SILQEMERVLHVGGTIVLLLSEDH 412
*********************************************999986....5799999999999*****999864 PP
>> tr|H7C0R6|H7C0R6_HUMAN THUMP domain-containing protein 3 (Fragment) OS=Homo sapiens GN=THUMPD3 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 64.9 0.0 8.9e-21 3.7e-17 2 86 .. 151 221 .. 149 231 .. 0.78
Alignments for each domain:
== domain 1 score: 64.9 bits; conditional E-value: 8.9e-21
SSS-SS---SS-HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-H CS
UPF0020 2 gyRefngpapLketLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldr 86
++++f gp++L++tLA++++rl++ p + ++DPmCG+G+i+IE+a+ ++++ +++ ++++ + ++++++++
tr|H7C0R6|H7C0R6_HUMAN 151 NITHF-GPTTLRSTLAYGMLRLCDPLPYDIIVDPMCGTGAIPIEGATEWSDCFHIAG-------------DNNPLAVNRAANNIA 221
55555.5**********************************************8776.............444444444444444 PP
>> tr|F2Z2Q4|F2Z2Q4_HUMAN tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens GN=TRMT11 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 45.1 0.0 1.1e-14 4.5e-11 3 140 .. 190 320 .. 189 332 .. 0.86
Alignments for each domain:
== domain 1 score: 45.1 bits; conditional E-value: 1.1e-14
SS-SS---SS-HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHH CS
UPF0020 3 yRefngpapLketLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvv 89
+R+f g++++ + L+ + + ++k+++ +DP+ G+G++lI a ga+++ + ++ + + +++r+++k +g D +
tr|F2Z2Q4|F2Z2Q4_HUMAN 190 KRHFIGNTSMDAGLSFIMANHGKVKENDIVFDPFVGTGGLLIACAHFGAYVY---GTDIDYNTVHGLGKATRKNQKWRGPDENI--- 270
79**************************************************...56678888888999999999******876... PP
HHHHHHHHHTT-GGG.EEEEE--GGG--.STTS---EEEE----------HHH CS
UPF0020 90 qgareNaekagvgdl.iefsqadaakLr.lkegevdvivtnpPYGerlgskka 140
r N++++g+++ ++ + da k +k +d+i+t+pPYG+r ++ ++
tr|F2Z2Q4|F2Z2Q4_HUMAN 271 ---RANLRQYGLEKYyLDVLVSDASKPSwRKGTYFDAIITDPPYGIRESTRRT 320
...5799999999852455666666655435559************9888765 PP
>> sp|Q7Z4G4|TRM11_HUMAN tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens GN=TRMT11 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 44.1 0.0 2.1e-14 9e-11 3 140 .. 190 320 .. 189 326 .. 0.85
Alignments for each domain:
== domain 1 score: 44.1 bits; conditional E-value: 2.1e-14
SS-SS---SS-HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHH CS
UPF0020 3 yRefngpapLketLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvq 90
+R+f g++++ + L+ + + ++k+++ +DP+ G+G++lI a ga+++ + ++ + + +++r+++k +g D +
sp|Q7Z4G4|TRM11_HUMAN 190 KRHFIGNTSMDAGLSFIMANHGKVKENDIVFDPFVGTGGLLIACAHFGAYVY---GTDIDYNTVHGLGKATRKNQKWRGPDENI---- 270
79**************************************************...56678888888999999999******876.... PP
HHHHHHHHTT-GGG.EEEEE--GGG--.STTS---EEEE----------HHH CS
UPF0020 91 gareNaekagvgdl.iefsqadaakLr.lkegevdvivtnpPYGerlgskka 140
r N++++g+++ ++ + da k +k +d+i+t+pPYG+r ++ ++
sp|Q7Z4G4|TRM11_HUMAN 271 --RANLRQYGLEKYyLDVLVSDASKPSwRKGTYFDAIITDPPYGIRESTRRT 320
..5799999999852455666666655435559*************888765 PP
>> sp|Q7Z4G4-2|TRM11_HUMAN Isoform 2 of tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens GN=TRMT11
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 44.1 0.0 2.1e-14 8.8e-11 3 140 .. 190 320 .. 189 326 .. 0.85
Alignments for each domain:
== domain 1 score: 44.1 bits; conditional E-value: 2.1e-14
SS-SS---SS-HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHH CS
UPF0020 3 yRefngpapLketLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrv 88
+R+f g++++ + L+ + + ++k+++ +DP+ G+G++lI a ga+++ + ++ + + +++r+++k +g D +
sp|Q7Z4G4-2|TRM11_HUMAN 190 KRHFIGNTSMDAGLSFIMANHGKVKENDIVFDPFVGTGGLLIACAHFGAYVY---GTDIDYNTVHGLGKATRKNQKWRGPDENI-- 270
79**************************************************...56678888888999999999******876.. PP
HHHHHHHHHHTT-GGG.EEEEE--GGG--.STTS---EEEE----------HHH CS
UPF0020 89 vqgareNaekagvgdl.iefsqadaakLr.lkegevdvivtnpPYGerlgskka 140
r N++++g+++ ++ + da k +k +d+i+t+pPYG+r ++ ++
sp|Q7Z4G4-2|TRM11_HUMAN 271 ----RANLRQYGLEKYyLDVLVSDASKPSwRKGTYFDAIITDPPYGIRESTRRT 320
....5799999999852455666666655435559*************888765 PP
>> tr|H0Y768|H0Y768_HUMAN tRNA (guanine(10)-N2)-methyltransferase homolog (Fragment) OS=Homo sapiens GN=TRMT11 PE=4 SV=
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 38.4 0.0 1.2e-12 4.9e-09 16 140 .. 2 119 .. 1 125 [. 0.82
Alignments for each domain:
== domain 1 score: 38.4 bits; conditional E-value: 1.2e-12
HHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHHHHHHHHHTT-G CS
UPF0020 16 LAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqgareNaekagvg 102
L+ + + ++k+++ +DP+ G+G++lI a ga+++ + ++ + + +++r+++k +g D + r N++++g++
tr|H0Y768|H0Y768_HUMAN 2 LSFIMANHGKVKENDIVFDPFVGTGGLLIACAHFGAYVY---GTDIDYNTVHGLGKATRKNQKWRGPDENI------RANLRQYGLE 79
5666888999*****************************...56678888888999999999******876......5799999999 PP
GG.EEEEE--GGG--.STTS---EEEE----------HHH CS
UPF0020 103 dl.iefsqadaakLr.lkegevdvivtnpPYGerlgskka 140
+ ++ + da k +k +d+i+t+pPYG+r ++ ++
tr|H0Y768|H0Y768_HUMAN 80 KYyLDVLVSDASKPSwRKGTYFDAIITDPPYGIRESTRRT 119
852455666666655435559*************888775 PP
>> tr|B8ZZE3|B8ZZE3_HUMAN Methyltransferase like 5, isoform CRA_b OS=Homo sapiens GN=METTL5 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 30.4 0.1 3.3e-10 1.4e-06 37 143 .. 60 141 .. 25 174 .. 0.74
Alignments for each domain:
== domain 1 score: 30.4 bits; conditional E-value: 3.3e-10
-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--.STTS-- CS
UPF0020 37 CGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqgareNaekagvgdliefsqadaakLr.lkegev 122
CG G + I a+lga +g+D+d+ +++ ++Nae+ ++++ i+++q d++ L ++++++
tr|B8ZZE3|B8ZZE3_HUMAN 60 CGCGVLSIGTAMLGAGLC-------------------------VGFDIDEDALEIFNRNAEEFELTN-IDMVQCDVCLLSnRMSKSF 120
555555555555555555.........................8********************986.788888*****998999** PP
-EEEE----------HHHHHH CS
UPF0020 123 dvivtnpPYGerlgskkalek 143
d+++ npP+G + ++ ++
tr|B8ZZE3|B8ZZE3_HUMAN 121 DTVIMNPPFGTKNNKGTDMAF 141
**********98776665544 PP
>> sp|Q9NRN9|METL5_HUMAN Methyltransferase-like protein 5 OS=Homo sapiens GN=METTL5 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 30.2 0.2 3.9e-10 1.7e-06 37 142 .. 60 140 .. 25 174 .. 0.74
Alignments for each domain:
== domain 1 score: 30.2 bits; conditional E-value: 3.9e-10
-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--.STTS--- CS
UPF0020 37 CGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqgareNaekagvgdliefsqadaakLr.lkegevd 123
CG G + I a+lga +g+D+d+ +++ ++Nae+ ++++ i+++q d++ L ++++++d
sp|Q9NRN9|METL5_HUMAN 60 CGCGVLSIGTAMLGAGLC-------------------------VGFDIDEDALEIFNRNAEEFELTN-IDMVQCDVCLLSnRMSKSFD 121
555555555555555555.........................8********************986.788888*****998999*** PP
EEEE----------HHHHH CS
UPF0020 124 vivtnpPYGerlgskkale 142
+++ npP+G + ++ ++
sp|Q9NRN9|METL5_HUMAN 122 TVIMNPPFGTKNNKGTDMA 140
*********9877666554 PP
>> tr|E7EMN2|E7EMN2_HUMAN Methyltransferase-like protein 5 OS=Homo sapiens GN=METTL5 PE=2 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 29.6 0.1 5.9e-10 2.5e-06 37 135 .. 60 133 .. 25 140 .. 0.75
Alignments for each domain:
== domain 1 score: 29.6 bits; conditional E-value: 5.9e-10
-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--.STTS-- CS
UPF0020 37 CGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqgareNaekagvgdliefsqadaakLr.lkegev 122
CG G + I a+lga +g+D+d+ +++ ++Nae+ ++++ i+++q d++ L ++++++
tr|E7EMN2|E7EMN2_HUMAN 60 CGCGVLSIGTAMLGAGLC-------------------------VGFDIDEDALEIFNRNAEEFELTN-IDMVQCDVCLLSnRMSKSF 120
555555555555555555.........................8********************986.788888*****998999** PP
-EEEE-------- CS
UPF0020 123 dvivtnpPYGerl 135
d+++ npP+G +
tr|E7EMN2|E7EMN2_HUMAN 121 DTVIMNPPFGTKN 133
**********875 PP
>> tr|B8ZZC8|B8ZZC8_HUMAN Methyltransferase-like protein 5 OS=Homo sapiens GN=METTL5 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 29.5 0.2 6.1e-10 2.6e-06 45 142 .. 68 140 .. 25 171 .. 0.74
Alignments for each domain:
== domain 1 score: 29.5 bits; conditional E-value: 6.1e-10
HHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--.STTS---EEEE--- CS
UPF0020 45 EaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqgareNaekagvgdliefsqadaakLr.lkegevdvivtnpP 130
a+lga +g+D+d+ +++ ++Nae+ ++++ i+++q d++ L ++++++d+++ npP
tr|B8ZZC8|B8ZZC8_HUMAN 68 GTAMLGAGLC-------------------------VGFDIDEDALEIFNRNAEEFELTN-IDMVQCDVCLLSnRMSKSFDTVIMNPP 128
5555555554.........................8********************986.788888*****998999********** PP
-------HHHHH CS
UPF0020 131 YGerlgskkale 142
+G + ++ ++
tr|B8ZZC8|B8ZZC8_HUMAN 129 FGTKNNKGTDMA 140
**9877666554 PP
>> sp|Q96RS0|TGS1_HUMAN Trimethylguanosine synthase OS=Homo sapiens GN=TGS1 PE=1 SV=3
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 23.9 0.0 3.4e-08 0.00014 48 132 .. 710 767 .. 677 769 .. 0.83
Alignments for each domain:
== domain 1 score: 23.9 bits; conditional E-value: 3.4e-08
HHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--STTS---EEEE----- CS
UPF0020 48 llganiapgllrefvlelkaeaeeearaelklygsDldrrvvqgareNaekagvgdliefsqadaakLrlkegevdvivtnpPYG 132
l g +++++D+d+ ++ ar+Nae +g++d+ief + d+ L + + dv+ pP+G
sp|Q96RS0|TGS1_HUMAN 710 LTGM--------------------------RVIAIDIDPVKIALARNNAEVYGIADKIEFICGDFLLLA-SFLKADVVFLSPPWG 767
4444..........................4669********************************999.9999**********9 PP
>> sp|Q7Z4G4-3|TRM11_HUMAN Isoform 3 of tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens GN=TRMT11
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 24.8 0.0 1.8e-08 7.4e-05 3 54 .. 190 241 .. 189 250 .. 0.94
Alignments for each domain:
== domain 1 score: 24.8 bits; conditional E-value: 1.8e-08
SS-SS---SS-HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT-- CS
UPF0020 3 yRefngpapLketLAaalvrlagwkpgepllDPmCGsGtilIEaallgania 54
+R+f g++++ + L+ + + ++k+++ +DP+ G+G++lI a ga+++
sp|Q7Z4G4-3|TRM11_HUMAN 190 KRHFIGNTSMDAGLSFIMANHGKVKENDIVFDPFVGTGGLLIACAHFGAYVY 241
79****************************************9999998887 PP
>> sp|Q9Y5R4|HEMK1_HUMAN HemK methyltransferase family member 1 OS=Homo sapiens GN=HEMK1 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 20.8 0.0 2.8e-07 0.0012 77 131 .. 184 242 .. 174 252 .. 0.90
Alignments for each domain:
== domain 1 score: 20.8 bits; conditional E-value: 2.8e-07
--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--....STTS---EEEE---- CS
UPF0020 77 lklygsDldrrvvqgareNaekagvgdliefsqadaakLr....lkegevdvivtnpPY 131
+++++D+ ++++ + eNa++ +++d+i + +d+++ r l+ g +d+iv+npPY
sp|Q9Y5R4|HEMK1_HUMAN 184 SRVIAVDKREAAISLTHENAQRLRLQDRIWIIHLDMTSERswthLPWGPMDLIVSNPPY 242
4599********************************998877778899*********** PP
>> tr|H7C0M7|H7C0M7_HUMAN Methyltransferase-like protein 5 (Fragment) OS=Homo sapiens GN=METTL5 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 20.3 0.0 4e-07 0.0017 94 144 .. 3 53 .. 1 88 [. 0.77
Alignments for each domain:
== domain 1 score: 20.3 bits; conditional E-value: 4e-07
HHHHHTT-GGGEEEEE--GGG--.STTS---EEEE----------HHHHHHH CS
UPF0020 94 eNaekagvgdliefsqadaakLr.lkegevdvivtnpPYGerlgskkalekL 144
+Nae+ +++ i+++q d++ L ++++++d+++ npP+G + ++ ++ L
tr|H7C0M7|H7C0M7_HUMAN 3 RNAEEFELT-NIDMVQCDVCLLSnRMSKSFDTVIMNPPFGTKNNKGTDMAFL 53
577777776.5889999*****998999************987766665444 PP
>> tr|F2Z2W7|F2Z2W7_HUMAN tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens GN=TRMT2A PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 16.2 0.0 7.5e-06 0.032 12 116 .. 416 511 .. 409 530 .. 0.79
Alignments for each domain:
== domain 1 score: 16.2 bits; conditional E-value: 7.5e-06
S-HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHHHHHHHHH CS
UPF0020 12 LketLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqgareNaek 98
e L ++ a++++g++ lD CG+Gti + a + +p r++++ + + +++g++l +++v+ ar Na+
tr|F2Z2W7|F2Z2W7_HUMAN 416 AAEVLYTVIQDWAQLDAGSMVLDVCCGTGTIGLALARGPMYSPPWVGRHHAFL-FQ-------KVKRVIGVELCPEAVEDARVNAQD 494
556666677788999****************9998888888888888776654.22.......23349******************* PP
TT-GGGEEEEE--GGG-- CS
UPF0020 99 agvgdliefsqadaakLr 116
+++ +ef + a +L
tr|F2Z2W7|F2Z2W7_HUMAN 495 NELS-NVEFHCGRAEDLV 511
9987.4788888888775 PP
>> sp|Q8IZ69-2|TRM2A_HUMAN Isoform 2 of tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens GN=TRMT2A
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 8.0 0.5 0.0024 10 14 101 .. 418 479 .. 409 512 .. 0.66
Alignments for each domain:
== domain 1 score: 8.0 bits; conditional E-value: 0.0024
HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHHHHHHHHHT CS
UPF0020 14 etLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqgareNaeka 99
e L ++ a++++g++ lD CG+Gti + a +++++ g++l +++v+ ar Na+
sp|Q8IZ69-2|TRM2A_HUMAN 418 EVLYTVIQDWAQLDAGSMVLDVCCGTGTIGLALARKVKRVI--------------------------GVELCPEAVEDARVNAQDN 477
55556667778889999999999999999776665555555..........................5555555555555555555 PP
T- CS
UPF0020 100 gv 101
++
sp|Q8IZ69-2|TRM2A_HUMAN 478 EL 479
54 PP
>> sp|Q8IZ69|TRM2A_HUMAN tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens GN=TRMT2A PE=1 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 7.8 0.5 0.0028 12 14 101 .. 418 479 .. 409 512 .. 0.66
Alignments for each domain:
== domain 1 score: 7.8 bits; conditional E-value: 0.0028
HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHHHHHHHHHTT- CS
UPF0020 14 etLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqgareNaekagv 101
e L ++ a++++g++ lD CG+Gti + a +++++ g++l +++v+ ar Na+ ++
sp|Q8IZ69|TRM2A_HUMAN 418 EVLYTVIQDWAQLDAGSMVLDVCCGTGTIGLALARKVKRVI--------------------------GVELCPEAVEDARVNAQDNEL 479
55556667778889999999999999999776665555555..........................555555555555555555554 PP
>> tr|F8VVX6|F8VVX6_HUMAN 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (Fragment) OS=Homo sapiens GN
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 10.5 0.0 0.00043 1.8 64 124 .. 60 131 .. 21 172 .. 0.68
Alignments for each domain:
== domain 1 score: 10.5 bits; conditional E-value: 0.00043
S.........HHHHHHHHHH..HH--..EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--STTS---E CS
UPF0020 64 e.........lkaeaeeear..aelk..lygsDldrrvvqgareNaekagvgdliefsqadaakLrlkegevdv 124
+ +e ++e+ ++ D+++++++ ++++a + g +++ da +L+ +++++d+
tr|F8VVX6|F8VVX6_HUMAN 60 RaqqnlsweeIAKEYQNEEDslG--GsrVVVCDINKEMLKVGKQKALAQGYRAGLAWVLGDAEELPFDDDKFDI 131
14445544433344444433333..1459999**********************************88888886 PP
>> tr|K7ENP1|K7ENP1_HUMAN tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens GN=TRMT11 PE=2 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 10.4 0.0 0.00044 1.8 3 39 .. 190 226 .. 189 228 .. 0.96
Alignments for each domain:
== domain 1 score: 10.4 bits; conditional E-value: 0.00044
SS-SS---SS-HHHHHHHHHHTT--TTS-EEETT-TT CS
UPF0020 3 yRefngpapLketLAaalvrlagwkpgepllDPmCGs 39
+R+f g++++ + L+ + + ++k+++ +DP+ G+
tr|K7ENP1|K7ENP1_HUMAN 190 KRHFIGNTSMDAGLSFIMANHGKVKENDIVFDPFVGT 226
79*********************************98 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (197 nodes)
Target sequences: 88473 (35070517 residues searched)
Passed MSV filter: 2165 (0.0244707); expected 1769.5 (0.02)
Passed bias filter: 1680 (0.0189888); expected 1769.5 (0.02)
Passed Vit filter: 130 (0.00146937); expected 88.5 (0.001)
Passed Fwd filter: 21 (0.000237361); expected 0.9 (1e-05)
Initial search space (Z): 88473 [actual number of targets]
Domain search space (domZ): 21 [number of targets reported over threshold]
# CPU time: 0.61u 0.03s 00:00:00.64 Elapsed: 00:00:00.25
# Mc/sec: 27635.57
//
[ok]