# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/UPF0020.hmm.txt
# target sequence database: proteomes/Monodelphis_domestica.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: UPF0020 [M=197]
Accession: PF01170.17
Description: Putative RNA methylase family UPF0020
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
1.1e-52 178.8 0.0 1.9e-52 178.1 0.0 1.3 1 tr|F6QGW7|F6QGW7_MONDO Uncharacterized protein OS=Monodelphi
1.4e-24 87.1 0.0 4.6e-24 85.4 0.0 1.8 1 tr|F7EY46|F7EY46_MONDO THUMP domain containing 2 OS=Monodelp
9.4e-11 42.0 0.0 2.4e-10 40.7 0.0 1.6 1 tr|F7GFQ3|F7GFQ3_MONDO tRNA methyltransferase 11 homolog OS=
6.8e-08 32.7 0.5 7.5e-07 29.3 0.5 2.1 1 tr|F6ZXU0|F6ZXU0_MONDO Methyltransferase like 5 OS=Monodelph
7.3e-07 29.3 0.3 6.4e-06 26.2 0.3 2.1 1 tr|F7B9I4|F7B9I4_MONDO HemK methyltransferase family member
1.5e-06 28.3 0.1 6.9e-06 26.1 0.1 1.9 1 tr|F7ADF5|F7ADF5_MONDO Trimethylguanosine synthase 1 OS=Mono
------ inclusion threshold ------
0.028 14.3 0.0 0.065 13.1 0.0 1.8 1 tr|F6WVA7|F6WVA7_MONDO 2-methoxy-6-polyprenyl-1,4-benzoquino
0.062 13.2 0.1 0.21 11.5 0.0 1.9 2 tr|F6S9Y2|F6S9Y2_MONDO tRNA methyltransferase 2 homolog A OS
Domain annotation for each sequence (and alignments):
>> tr|F6QGW7|F6QGW7_MONDO Uncharacterized protein OS=Monodelphis domestica OX=13616 GN=THUMPD3 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 178.1 0.0 7e-56 1.9e-52 2 196 .. 303 486 .. 301 487 .. 0.96
Alignments for each domain:
== domain 1 score: 178.1 bits; conditional E-value: 7e-56
SSS-SS---SS-HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHH CS
UPF0020 2 gyRefngpapLketLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrv 88
++++f gp++L++tLA++++rl+ +p++ ++DPmCG+G+i+IE+a + n+++++ ++++ + ++++++ ++
tr|F6QGW7|F6QGW7_MONDO 303 NITHF-GPTTLRSTLAYGMLRLCSPQPTDIIIDPMCGTGAIPIEGAAEWPNCYHIAG-------------DNNPLAVKRAANNILSL 375
55555.5**********************************************7666.............88899999********* PP
HHHHHHHHHHTT-GGGEEEEE--GGG--STTS---EEEE----------HHHHHHHHHHHHHHHHHH-TT...-EEEEEESSHHHHH CS
UPF0020 89 vqgareNaekagvgdliefsqadaakLrlkegevdvivtnpPYGerlgskkalekLYseflrelkrvlrgg.grlvlltsenkalek 174
+++++ + +ka +g i++ q+d+++L+l++g+vd+ivt++P+G+r+gskk++++LY+++l+e++rv+r g gr+vllt+++k+++k
tr|F6QGW7|F6QGW7_MONDO 376 LTKSQVKESKAFWGLPIDAIQWDICNLPLRTGSVDIIVTDMPFGKRIGSKKRNWNLYPSCLQEMSRVCRPGtGRAVLLTQDRKCFAK 462
*********************************************************************999*************** PP
CC---..ESEEEEEEETTEEEEEE CS
UPF0020 175 aleer..alrkvkeknvklglllk 196
al+++ +rkv+ ++v++g+l++
tr|F6QGW7|F6QGW7_MONDO 463 ALSSMghVWRKVHTVWVNIGGLHA 486
*****999************9985 PP
>> tr|F7EY46|F7EY46_MONDO THUMP domain containing 2 OS=Monodelphis domestica OX=13616 GN=THUMPD2 PE=4 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 85.4 0.0 1.7e-27 4.6e-24 4 169 .. 227 366 .. 225 372 .. 0.93
Alignments for each domain:
== domain 1 score: 85.4 bits; conditional E-value: 1.7e-27
S-SS---SS-HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHH CS
UPF0020 4 RefngpapLketLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvq 90
R + + a L++t+A + la+++ g + lDPmCG Gtil+Eaa + n++ g+D + +
tr|F7EY46|F7EY46_MONDO 227 RAYIKVAGLRSTIAWTMASLAEINVGAVVLDPMCGLGTILLEAAKEWPNAY------------------------YLGADVSDSQLS 289
778889*********************************************........................79********** PP
HHHHHHHHTT-GGGEEEEE--GGG--STTS---EEEE----------HHHHHHHHHHHHHHHHHH-TT..-EEEEEESS CS
UPF0020 91 gareNaekagvgdliefsqadaakLrlkegevdvivtnpPYGerlgskkalekLYseflrelkrvlrgggrlvlltsen 169
ga +N+++ag+ d+ie+ + +++L+l +++vdvi+++ P+G++ + k+++++ +e+ r++ ++ g +vll+se+
tr|F7EY46|F7EY46_MONDO 290 GACDNLKSAGLVDRIELLKFSVTELPLLSKSVDVIISDIPFGKKFKLGKDIKSILHEMERQVLLCVGG--TIVLLLSEE 366
**************************9999**********************9999999988765555..888777765 PP
>> tr|F7GFQ3|F7GFQ3_MONDO tRNA methyltransferase 11 homolog OS=Monodelphis domestica OX=13616 GN=TRMT11 PE=4 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 40.7 0.0 9e-14 2.4e-10 3 140 .. 190 320 .. 189 325 .. 0.85
Alignments for each domain:
== domain 1 score: 40.7 bits; conditional E-value: 9e-14
SS-SS---SS-HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHH CS
UPF0020 3 yRefngpapLketLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvv 89
+R+f g++++ + L+ + + ++k+++ +DP+ G+G++lI a ga++ + ++ + + ++ r+++k +g D +
tr|F7GFQ3|F7GFQ3_MONDO 190 KRHFIGNTSMDAGLSFIMANHGKVKENDIVFDPFVGTGGLLIPSAHFGAYVC---GTDIDYNTVHGLGKASRKNQKWRGPDENI--- 270
79**************************************************...556777788888888999999*****875... PP
HHHHHHHHHTT-GGG.EEEEE--GGG--.STTS---EEEE----------HHH CS
UPF0020 90 qgareNaekagvgdl.iefsqadaakLr.lkegevdvivtnpPYGerlgskka 140
+ N++++g+++ ++ + da k +k +d+i+t+pPYG+r ++ k+
tr|F7GFQ3|F7GFQ3_MONDO 271 ---KANLRQYGLEKYyLDVLVSDASKPSwRKGLFFDAIITDPPYGIRESTRKT 320
...5799999999862466666777666445559*************888775 PP
>> tr|F6ZXU0|F6ZXU0_MONDO Methyltransferase like 5 OS=Monodelphis domestica OX=13616 GN=METTL5 PE=4 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 29.3 0.5 2.8e-10 7.5e-07 13 141 .. 29 136 .. 22 172 .. 0.76
Alignments for each domain:
== domain 1 score: 29.3 bits; conditional E-value: 2.8e-10
-HHHHHHHHHHTT--....TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHHHHHH CS
UPF0020 13 ketLAaalvrlagwk....pgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqgareN 95
++ +Aa++++ + +++++ D CG G + I aa+lga +g+D+d+ +++ ++N
tr|F6ZXU0|F6ZXU0_MONDO 29 RPHIAACMLYTIHNTyddiENKVIGDLGCGCGMLSIGAAMLGAGLC-------------------------VGFDIDEDALEIFNKN 90
6777777776655441111445788888999999999999999888.........................8*************** PP
HHHTT-GGGEEEEE--GGG--.STTS---EEEE----------HHHH CS
UPF0020 96 aekagvgdliefsqadaakLr.lkegevdvivtnpPYGerlgskkal 141
++ ++++ i++ q ++++L ++++d+i+ npP+G + ++ ++
tr|F6ZXU0|F6ZXU0_MONDO 91 VKEFELTN-IDMIQCNVCSLSeTISKSFDTIIMNPPFGTKHNKGMDM 136
*****986.777788******65566************987665544 PP
>> tr|F7B9I4|F7B9I4_MONDO HemK methyltransferase family member 1 OS=Monodelphis domestica OX=13616 GN=HEMK1 PE=4 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 26.2 0.3 2.4e-09 6.4e-06 76 131 .. 194 254 .. 164 267 .. 0.87
Alignments for each domain:
== domain 1 score: 26.2 bits; conditional E-value: 2.4e-09
H--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--.....STTS---EEEE---- CS
UPF0020 76 elklygsDldrrvvqgareNaekagvgdliefsqadaakLr.....lkegevdvivtnpPY 131
+ +++++D+ +++vq +reNa++ ++d+i+++ d+++ l+ g vd +v+npPY
tr|F7B9I4|F7B9I4_MONDO 194 QSRVVAVDKGEEAVQLTRENAQRLHLEDRIQIVRHDITSGVnreqlLPWGPVDFVVSNPPY 254
33499*******************************98643355666788*********** PP
>> tr|F7ADF5|F7ADF5_MONDO Trimethylguanosine synthase 1 OS=Monodelphis domestica OX=13616 GN=TGS1 PE=4 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 26.1 0.1 2.6e-09 6.9e-06 31 132 .. 582 656 .. 577 658 .. 0.92
Alignments for each domain:
== domain 1 score: 26.1 bits; conditional E-value: 2.6e-09
-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--S CS
UPF0020 31 pllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqgareNaekagvgdliefsqadaakLrl 117
++D +CG G+ +I al g++++ ++D+d++ ++ a +Nae +gv+d+ief + d+ L
tr|F7ADF5|F7ADF5_MONDO 582 IIVDAFCGVGGNAIQFALTGKRVI--------------------------AIDIDPAKIDLAHNNAEVYGVADKIEFICGDFMLLA- 641
688888888888888888888888..........................9********************************999. PP
TTS---EEEE----- CS
UPF0020 118 kegevdvivtnpPYG 132
++ + dv+ pP+G
tr|F7ADF5|F7ADF5_MONDO 642 SDLKADVVFLSPPWG 656
8889**********9 PP
>> tr|F6WVA7|F6WVA7_MONDO 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Monodelphis domestica OX=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 13.1 0.0 2.5e-05 0.065 71 124 .. 147 203 .. 89 231 .. 0.72
Alignments for each domain:
== domain 1 score: 13.1 bits; conditional E-value: 2.5e-05
HHHH...HH--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--STTS---E CS
UPF0020 71 eear...aelklygsDldrrvvqgareNaekagvgdliefsqadaakLrlkegevdv 124
++ + +e +++ D+++++++ ++++a+ g ++ ++++ da +L+ +++++d+
tr|F6WVA7|F6WVA7_MONDO 147 QNGQgpsEESHVVVCDINKEMLKVGKQKAKTLGHKKGLAWVVGDAEELPFDDDKFDI 203
222245455669999**********************************88888885 PP
>> tr|F6S9Y2|F6S9Y2_MONDO tRNA methyltransferase 2 homolog A OS=Monodelphis domestica OX=13616 GN=TRMT2A PE=3 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -2.2 0.0 1.3 3.4e+03 129 175 .. 190 235 .. 187 244 .. 0.79
2 ? 11.5 0.0 7.7e-05 0.21 20 92 .. 436 501 .. 421 513 .. 0.82
Alignments for each domain:
== domain 1 score: -2.2 bits; conditional E-value: 1.3
---------HHHH.HHHHHHHHHHHHHH-TT..-EEEEEESSHHHHHC CS
UPF0020 129 pPYGerlgskkal.ekLYseflrelkrvlrgggrlvlltsenkaleka 175
+PY e l++k++ e+ +++ +e+ ++ r+ l l+ ++++++k+
tr|F6S9Y2|F6S9Y2_MONDO 190 LPYEEQLERKQQEcEQVLQKLTKEIGNNNRT--LLPWLFVQKQKFNKL 235
6999999998877788888888888887777..777788888888776 PP
== domain 2 score: 11.5 bits; conditional E-value: 7.7e-05
HHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHHH CS
UPF0020 20 lvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqga 92
+ a+++ + + lD CG+Gti + a+ +++++ +el +ea e+ar+++k+ ++D+++ + +a
tr|F6S9Y2|F6S9Y2_MONDO 436 IRDWAQLDGEITVLDVCCGTGTIGLSLAQTVKRVI-------GIELCQEAVEDARVNAKMNALDNIEFHCGKA 501
5566777888899999***********99999999.......5678999999999999999999988776666 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (197 nodes)
Target sequences: 21272 (11266248 residues searched)
Passed MSV filter: 556 (0.0261376); expected 425.4 (0.02)
Passed bias filter: 453 (0.0212956); expected 425.4 (0.02)
Passed Vit filter: 46 (0.00216247); expected 21.3 (0.001)
Passed Fwd filter: 8 (0.000376081); expected 0.2 (1e-05)
Initial search space (Z): 21272 [actual number of targets]
Domain search space (domZ): 8 [number of targets reported over threshold]
# CPU time: 0.23u 0.01s 00:00:00.24 Elapsed: 00:00:00.11
# Mc/sec: 20176.83
//
[ok]