# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/UPF0020.hmm.txt
# target sequence database: proteomes/Mus_musculus.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: UPF0020 [M=197]
Accession: PF01170.17
Description: Putative RNA methylase family UPF0020
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
7.3e-56 189.3 0.0 1.2e-55 188.6 0.0 1.3 1 sp|P97770|THUM3_MOUSE THUMP domain-containing protein 3 OS=M
4.9e-26 92.0 0.2 3e-25 89.4 0.0 2.3 2 sp|Q9CZB3|THUM2_MOUSE THUMP domain-containing protein 2 OS=M
2.2e-12 47.4 0.0 5.3e-12 46.1 0.0 1.5 1 sp|Q9CWH5|TRM11_MOUSE tRNA (guanine(10)-N2)-methyltransferas
1.2e-06 28.6 0.4 1.4e-05 25.2 0.3 2.2 1 sp|Q8K1A0|METL5_MOUSE Methyltransferase-like protein 5 OS=Mu
9e-06 25.8 0.0 4.6e-05 23.5 0.0 2.1 1 sp|Q923W1|TGS1_MOUSE Trimethylguanosine synthase OS=Mus mus
9.6e-05 22.5 0.0 0.00024 21.1 0.0 1.6 1 sp|Q921L7|HEMK1_MOUSE HemK methyltransferase family member 1
------ inclusion threshold ------
0.095 12.7 0.0 0.16 12.0 0.0 1.6 1 sp|Q6SKR2|N6MT1_MOUSE Methyltransferase N6AMT1 OS=Mus muscul
0.16 11.9 0.0 6.9 6.6 0.0 2.3 2 sp|B2KFW1|ZSC20_MOUSE Zinc finger and SCAN domain-containing
Domain annotation for each sequence (and alignments):
>> sp|P97770|THUM3_MOUSE THUMP domain-containing protein 3 OS=Mus musculus OX=10090 GN=Thumpd3 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 188.6 0.0 4.3e-59 1.2e-55 2 196 .. 296 479 .. 294 480 .. 0.96
Alignments for each domain:
== domain 1 score: 188.6 bits; conditional E-value: 4.3e-59
SSS-SS---SS-HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHH CS
UPF0020 2 gyRefngpapLketLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvv 89
++++f gp++L++tLA++++rl++ kp+++++DPmCG+G+i+IE+a+ ++++++++ ++++ + +++++++++++
sp|P97770|THUM3_MOUSE 296 NITHF-GPTTLRSTLAYGMLRLCEPKPTDVIVDPMCGTGAIPIEGATEWSHCYHIAG-------------DNNPLAVNRAANNISSLL 369
55555.5**********************************************7665.............8999999*********** PP
HHHHHHHHHTT-GGGEEEEE--GGG--STTS---EEEE----------HHHHHHHHHHHHHHHHHH-TT...-EEEEEESSHHHHHCC CS
UPF0020 90 qgareNaekagvgdliefsqadaakLrlkegevdvivtnpPYGerlgskkalekLYseflrelkrvlrgg.grlvlltsenkalekal 176
++++ ++ k+++g i+++q+d+++L+l++++vd+ivt++P+G+r+gskk++++LY+++lre++rv+r g gr+vllt+++k+++kal
sp|P97770|THUM3_MOUSE 370 TKSQIKDGKTTWGLPIDAVQWDICNLPLRTASVDIIVTDMPFGKRMGSKKRNWNLYPACLREMSRVCRPGtGRAVLLTQDKKCFTKAL 457
********************************************************************999***************** PP
---..ESEEEEEEETTEEEEEE CS
UPF0020 177 eer..alrkvkeknvklglllk 196
+ + +rkv++++v++g+l++
sp|P97770|THUM3_MOUSE 458 SGMghVWRKVHVVWVNIGGLHA 479
***999************9985 PP
>> sp|Q9CZB3|THUM2_MOUSE THUMP domain-containing protein 2 OS=Mus musculus OX=10090 GN=Thumpd2 PE=2 SV=3
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -1.7 0.0 0.9 2.5e+03 106 127 .. 124 145 .. 120 212 .. 0.79
2 ! 89.4 0.0 1.1e-28 3e-25 4 170 .. 274 412 .. 272 425 .. 0.94
Alignments for each domain:
== domain 1 score: -1.7 bits; conditional E-value: 0.9
EEEE--GGG--STTS---EEEE CS
UPF0020 106 efsqadaakLrlkegevdvivt 127
++sq da L++k ge+++i++
sp|Q9CZB3|THUM2_MOUSE 124 KVSQRDANPLKRKAGENETIIA 145
5677777777777777777775 PP
== domain 2 score: 89.4 bits; conditional E-value: 1.1e-28
S-SS---SS-HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHH CS
UPF0020 4 RefngpapLketLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqg 91
R + + a L++t+A a+ +a++k+g lDPmCG Gtil+Eaa + ++ +g+D+ + + g
sp|Q9CZB3|THUM2_MOUSE 274 RTYIQTAGLRSTIAWAMASIAEIKAGALVLDPMCGLGTILVEAAEEWPDVF------------------------YMGADMSDAQLLG 337
788899*********************************************........................79*********** PP
HHHHHHHTT-GGGEEEEE--GGG--STTS---EEEE----------HHHHHHHHHHHHHHHHHH-TT..-EEEEEESSH CS
UPF0020 92 areNaekagvgdliefsqadaakLrlkegevdvivtnpPYGerlgskkalekLYseflrelkrvlrgggrlvlltsenk 170
a +N+++ag++d+ie+ + +++L+l++++ dvi+++ P+G++ + k+++ ++l+e++rvlr gg +vll+se+
sp|Q9CZB3|THUM2_MOUSE 338 ACDNLKAAGLTDRIELLKSSVTDLPLPSQSTDVIISDIPFGKKFKLGKDIK----SILQEMERVLRVGGAMVLLLSEDH 412
*********************************************999986....58999*******999999999864 PP
>> sp|Q9CWH5|TRM11_MOUSE tRNA (guanine(10)-N2)-methyltransferase homolog OS=Mus musculus OX=10090 GN=Trmt11 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 46.1 0.0 1.9e-15 5.3e-12 3 140 .. 190 320 .. 189 324 .. 0.86
Alignments for each domain:
== domain 1 score: 46.1 bits; conditional E-value: 1.9e-15
SS-SS---SS-HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHH CS
UPF0020 3 yRefngpapLketLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvq 90
+R+f g++++ + L+ + + a++k+++ +DP+ G+G++lI a ga++ + ++ + + ++ r+++k +g D +
sp|Q9CWH5|TRM11_MOUSE 190 KRHFIGNTSMDAGLSFIMTNHAKVKENDLVFDPFVGTGGLLIASAHFGAYVC---GTDIDYNTVHGLGKASRKNQKWRGPDENI---- 270
79**************************************************...556777788888888999999*****876.... PP
HHHHHHHHTT-GGG.EEEEE--GGG--.STTS---EEEE----------HHH CS
UPF0020 91 gareNaekagvgdl.iefsqadaakLr.lkegevdvivtnpPYGerlgskka 140
r N++++g++++ ++ + da k +k +d+i+t+pPYG+r ++ ++
sp|Q9CWH5|TRM11_MOUSE 271 --RANLRQYGLEKFyLDVLVSDASKPSwRKGTYFDAIITDPPYGIRESTRRS 320
..57*******9973356666666655445559*************888776 PP
>> sp|Q8K1A0|METL5_MOUSE Methyltransferase-like protein 5 OS=Mus musculus OX=10090 GN=Mettl5 PE=2 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 25.2 0.3 4.9e-09 1.4e-05 13 148 .. 32 146 .. 25 170 .. 0.79
Alignments for each domain:
== domain 1 score: 25.2 bits; conditional E-value: 4.9e-09
-HHHHHHHHHHTT--....TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHHHHHHH CS
UPF0020 13 ketLAaalvrlagwk....pgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqgareNa 96
++ +Aa++++ + +++ +D CG G + I aa+lga +g+D+d+ +++ ++N
sp|Q8K1A0|METL5_MOUSE 32 RPHIAACMLYTIHNTyddiENKAVADLGCGCGVLSIGAAMLGAGLC-------------------------VGFDIDEDALEIFNKNV 94
6677777766555441111345678888888888888888888888.........................8**************** PP
HHTT-GGGEEEEE--GGG--.STTS---EEEE----------HHHHHHHHHHH CS
UPF0020 97 ekagvgdliefsqadaakLr.lkegevdvivtnpPYGerlgskkalekLYsef 148
e+ ++++ +++ q d+ +L ++++ +d+++ npP+G + ++ ++ L ++
sp|Q8K1A0|METL5_MOUSE 95 EEFELTN-VDMIQCDVYSLSnRMSKLFDTVIMNPPFGTKNNKGTDMAFLKTAL 146
****986.788888******888889***********9988777776666555 PP
>> sp|Q923W1|TGS1_MOUSE Trimethylguanosine synthase OS=Mus musculus OX=10090 GN=Tgs1 PE=1 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 23.5 0.0 1.7e-08 4.6e-05 31 132 .. 685 759 .. 667 761 .. 0.83
Alignments for each domain:
== domain 1 score: 23.5 bits; conditional E-value: 1.7e-08
-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--STT CS
UPF0020 31 pllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqgareNaekagvgdliefsqadaakLrlke 119
+ +D +CG G+ I al g++++ ++D+d+ ++ ar+Nae +g++d+ief + d+ L +
sp|Q923W1|TGS1_MOUSE 685 VVVDAFCGVGGNTIQFALTGKRVI--------------------------AIDIDPVKIDLARNNAEVYGIADKIEFICGDFLLLA-PC 746
556666666666666666666666..........................9********************************999.88 PP
S---EEEE----- CS
UPF0020 120 gevdvivtnpPYG 132
+ dv+ pP+G
sp|Q923W1|TGS1_MOUSE 747 LKADVVFLSPPWG 759
899*********9 PP
>> sp|Q921L7|HEMK1_MOUSE HemK methyltransferase family member 1 OS=Mus musculus OX=10090 GN=Hemk1 PE=2 SV=2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 21.1 0.0 8.7e-08 0.00024 76 134 .. 184 247 .. 157 257 .. 0.86
Alignments for each domain:
== domain 1 score: 21.1 bits; conditional E-value: 8.7e-08
H--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--.....STTS---EEEE------- CS
UPF0020 76 elklygsDldrrvvqgareNaekagvgdliefsqadaakLr.....lkegevdvivtnpPYGer 134
+ +++++D+++++v + eNa++ +++d+i + +d+++ l+ + d++v+npPY r
sp|Q921L7|HEMK1_MOUSE 184 KSRVVAVDKEEAAVSLTHENAQRLQLQDRIRIIHLDITSEGccthlLPWSPLDLVVSNPPYIFR 247
44599*******************************987444445668889**********766 PP
>> sp|Q6SKR2|N6MT1_MOUSE Methyltransferase N6AMT1 OS=Mus musculus OX=10090 GN=N6amt1 PE=1 SV=1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 12.0 0.0 5.7e-05 0.16 76 131 .. 70 125 .. 36 194 .. 0.92
Alignments for each domain:
== domain 1 score: 12.0 bits; conditional E-value: 5.7e-05
H--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--STTS---EEEE---- CS
UPF0020 76 elklygsDldrrvvqgareNaekagvgdliefsqadaakLrlkegevdvivtnpPY 131
++ ++ D+++++ +++ e a+ +v + + ++ + L++ +g+vd++v npPY
sp|Q6SKR2|N6MT1_MOUSE 70 RALYMCTDINPEAAACTLETARCNRVHVQPVITDLVHGLLPRLKGKVDLLVFNPPY 125
55579*****************************9999999*************** PP
>> sp|B2KFW1|ZSC20_MOUSE Zinc finger and SCAN domain-containing protein 20 OS=Mus musculus OX=10090 GN=Zscan20 PE=2 SV=
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 6.6 0.0 0.0025 6.9 94 153 .. 295 357 .. 282 385 .. 0.78
2 ? 2.6 0.0 0.041 1.2e+02 119 153 .. 484 518 .. 456 544 .. 0.85
Alignments for each domain:
== domain 1 score: 6.6 bits; conditional E-value: 0.0025
HHHHHTT-GGGEEEEE--GGG--...STTS---EEEE----------HHHHHHHHHHHHHHHH CS
UPF0020 94 eNaekagvgdliefsqadaakLr...lkegevdvivtnpPYGerlgskkalekLYseflrelk 153
++ g ++ ++++++ ++ ++++ + +i+++ P+ e+l++ +++++ Y++++++l
sp|B2KFW1|ZSC20_MOUSE 295 ADSRAWGEPCQWGAEDMKVSGVHwgyEETKTFLAILSESPFSEKLQTCHQNRQVYRAIAERLR 357
444444555556667788888889887888999************************998875 PP
== domain 2 score: 2.6 bits; conditional E-value: 0.041
TS---EEEE----------HHHHHHHHHHHHHHHH CS
UPF0020 119 egevdvivtnpPYGerlgskkalekLYseflrelk 153
++ + +i+++ P+ e+l + +++ ++Y++++++l
sp|B2KFW1|ZSC20_MOUSE 484 TKVFLAILSESPFAEKLRTCHQNSQIYRAIAERLR 518
4456689**********************998875 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (197 nodes)
Target sequences: 22289 (11757923 residues searched)
Passed MSV filter: 585 (0.0262461); expected 445.8 (0.02)
Passed bias filter: 462 (0.0207277); expected 445.8 (0.02)
Passed Vit filter: 36 (0.00161515); expected 22.3 (0.001)
Passed Fwd filter: 8 (0.000358921); expected 0.2 (1e-05)
Initial search space (Z): 22289 [actual number of targets]
Domain search space (domZ): 8 [number of targets reported over threshold]
# CPU time: 0.20u 0.01s 00:00:00.21 Elapsed: 00:00:00.08
# Mc/sec: 28953.89
//
[ok]