# hmmsearch :: search profile(s) against a sequence database
# HMMER 3.1b2 (February 2015); http://hmmer.org/
# Copyright (C) 2015 Howard Hughes Medical Institute.
# Freely distributed under the GNU General Public License (GPLv3).
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query HMM file: pfam_list/UPF0020.hmm.txt
# target sequence database: proteomes/Saccharomyces_cerevisiae.fasta
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: UPF0020 [M=197]
Accession: PF01170.17
Description: Putative RNA methylase family UPF0020
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
8.2e-12 43.7 0.0 1.4e-10 39.7 0.0 2.2 1 sp|Q12463|TRM11_YEAST tRNA (guanine(10)-N2)-methyltransferas
1.9e-06 26.2 0.1 2.4e-05 22.6 0.1 2.2 1 sp|Q12052|TGS1_YEAST Trimethylguanosine synthase OS=Sacchar
0.0019 16.4 0.0 0.055 11.6 0.0 2.1 2 sp|Q03920|MTQ2_YEAST eRF1 methyltransferase catalytic subun
------ inclusion threshold ------
0.015 13.5 0.0 0.039 12.1 0.0 1.6 1 sp|P40516|EFM4_YEAST Protein-lysine N-methyltransferase EFM
0.033 12.3 0.1 0.12 10.5 0.1 2.0 2 sp|P25087|ERG6_YEAST Sterol 24-C-methyltransferase OS=Sacch
Domain annotation for each sequence (and alignments):
>> sp|Q12463|TRM11_YEAST tRNA (guanine(10)-N2)-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 39.7 0.0 1.1e-13 1.4e-10 3 134 .. 184 297 .. 183 303 .. 0.79
Alignments for each domain:
== domain 1 score: 39.7 bits; conditional E-value: 1.1e-13
SS-SS---SS-HHHHHHHHHHTT--TTS-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHH CS
UPF0020 3 yRefngpapLketLAaalvrlagwkpgepllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvq 90
+R+++g ++ ++L+ + ++a++kpg+ ++DP+ G+G++l+ ++ g+ ++ gsD+d r+++
sp|Q12463|TRM11_YEAST 184 KRPYKGTTSFEAELSLVSANIAQVKPGTIMYDPFAGTGSFLVAGGHFGSLVI--------------------------GSDIDGRMIR 245
79***********************************************999..........................*********7 PP
..HHHHHHHHT..T-G...GGEEEEE--GGG--.STTS---EEEE------- CS
UPF0020 91 ..gareNaeka..gvg...dliefsqadaakLr.lkegevdvivtnpPYGer 134
ga+ N ++ + g ++ ++ ++d+++ +++ +d+i+++pPYG+r
sp|Q12463|TRM11_YEAST 246 gkGAQVNISANfkKYGessQFLDVLTMDFTNNAlRNNLVIDTILCDPPYGIR 297
3369988654311333001444555555554333366699**********99 PP
>> sp|Q12052|TGS1_YEAST Trimethylguanosine synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 22.6 0.1 2e-08 2.4e-05 30 132 .. 99 179 .. 81 231 .. 0.83
Alignments for each domain:
== domain 1 score: 22.6 bits; conditional E-value: 2e-08
S-EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--.. CS
UPF0020 30 epllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqgareNaekagvgdliefsqadaakLr.. 116
e++lD +CG+G+ I a++ +++ g+D +++ ++ +Na+++gv+d+i ++ +kL
sp|Q12052|TGS1_YEAST 99 ERILDVFCGGGGNTIQFAMQFPYVY--------------------------GVDYSIEHIYCTAKNAQSYGVDDRIWLKRGSWKKLVsk 161
5566666666666666666666665..........................***********************************977 PP
..STTS---EEEE----- CS
UPF0020 117 ..lkegevdvivtnpPYG 132
l++ ++d + + pP+G
sp|Q12052|TGS1_YEAST 162 qkLSKIKYDCVFGSPPWG 179
7555669**********9 PP
>> sp|Q03920|MTQ2_YEAST eRF1 methyltransferase catalytic subunit MTQ2 OS=Saccharomyces cerevisiae (strain ATCC 204508 /
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 11.6 0.0 4.6e-05 0.055 79 131 .. 73 125 .. 29 128 .. 0.79
2 ? 2.7 0.0 0.024 28 142 179 .. 156 193 .. 150 208 .. 0.83
Alignments for each domain:
== domain 1 score: 11.6 bits; conditional E-value: 4.6e-05
EEEEES-HHHHHHHHHHHH.HTT-GGGEEEEE--GGG--STTS---EEEE---- CS
UPF0020 79 lygsDldrrvvqgareNae.kagvgdliefsqadaakLrlkegevdvivtnpPY 131
++D+++ +++++ + a+ + + + + e+ qad + ++++vdv++ npPY
sp|Q03920|MTQ2_YEAST 73 HLAVDINPWALEATLDTAKlNSCKSSFLEVIQADLNSSI-RNNQVDVLIFNPPY 125
578999999999998888745677788899998887655.6779********** PP
== domain 2 score: 2.7 bits; conditional E-value: 0.024
HHHHHHHHHHHHHH-TT..-EEEEEESSHHHHHCC--- CS
UPF0020 142 ekLYseflrelkrvlrgggrlvlltsenkalekaleer 179
++++++lr+l+++l+ +g + +l+ ++++ ++++++
sp|Q03920|MTQ2_YEAST 156 MAITDKLLRQLEQILSPDGVAYILFCARNKPKEVIKRF 193
5678999*********************9999999876 PP
>> sp|P40516|EFM4_YEAST Protein-lysine N-methyltransferase EFM4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 12.1 0.0 3.3e-05 0.039 75 115 .. 116 156 .. 107 168 .. 0.81
Alignments for each domain:
== domain 1 score: 12.1 bits; conditional E-value: 3.3e-05
HH--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG- CS
UPF0020 75 aelklygsDldrrvvqgareNaekagvgdliefsqadaakL 115
+ kl+g+D ++ v+ a + ae++gv+++i+f+qad+ +
sp|P40516|EFM4_YEAST 116 FQGKLVGIDYSEESVKLASNIAEATGVDNFISFQQADIFSG 156
44569********************************8765 PP
>> sp|P25087|ERG6_YEAST Sterol 24-C-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=55929
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? 10.5 0.1 9.6e-05 0.12 76 125 .. 142 191 .. 101 217 .. 0.87
2 ? -3.5 0.0 2 2.4e+03 88 106 .. 256 274 .. 234 280 .. 0.77
Alignments for each domain:
== domain 1 score: 10.5 bits; conditional E-value: 9.6e-05
H--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--STTS---EE CS
UPF0020 76 elklygsDldrrvvqgareNaekagvgdliefsqadaakLrlkegevdvi 125
+++g++++ +++a+ a+k++++d+++f++ d+ k+ +e+ +d +
sp|P25087|ERG6_YEAST 142 GCNVIGLNNNDYQIAKAKYYAKKYNLSDQMDFVKGDFMKMDFEENTFDKV 191
45699***********************************9666678765 PP
== domain 2 score: -3.5 bits; conditional E-value: 2
HHHHHHHHHHHTT-GGGEE CS
UPF0020 88 vvqgareNaekagvgdlie 106
+v+ ar+ ++++g + l++
sp|P25087|ERG6_YEAST 256 HVDVARKALKNCGFEVLVS 274
5888999999999887775 PP
Internal pipeline statistics summary:
-------------------------------------
Query model(s): 1 (197 nodes)
Target sequences: 6049 (2936363 residues searched)
Passed MSV filter: 168 (0.0277732); expected 121.0 (0.02)
Passed bias filter: 137 (0.0226484); expected 121.0 (0.02)
Passed Vit filter: 18 (0.0029757); expected 6.0 (0.001)
Passed Fwd filter: 5 (0.000826583); expected 0.1 (1e-05)
Initial search space (Z): 6049 [actual number of targets]
Domain search space (domZ): 5 [number of targets reported over threshold]
# CPU time: 0.06u 0.00s 00:00:00.06 Elapsed: 00:00:00.03
# Mc/sec: 19282.12
//
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